Tried Wegovy — Is Mounjaro the Next Step?

Chelsea Green Pharmacy

If you’ve been using Wegovy (semaglutide) as part of your weight loss journey, you’re likely already familiar with the benefits of GLP-1 medications — reduced appetite, improved portion control, and gradual, sustainable fat loss. But what if your progress has started to slow down? Or perhaps the side effects have become difficult to manage?

At Chelsea Green Pharmacy, we’re seeing more and more patients ask us the same question: Wegovy vs Mounjaro — which is better, and should I consider switching?

In this blog, we’ll explain the difference between the two medications, explore why Mounjaro (tirzepatide) is generating such interest, and help you decide if a change in weight loss treatment might be right for you.

When Wegovy Plateaus: What’s Going On?

Wegovy has shown excellent results for many people. It works by mimicking GLP-1, a naturally occurring hormone that regulates appetite and blood sugar. For most patients, this leads to a significant reduction in hunger and calorie intake, which can support weight loss over time.

However, for some individuals:

  • Weight loss may plateau after several months

  • Side effects such as nausea, fatigue, or constipation become bothersome

  • The appetite-suppressing effect may wear off slightly

  • Progress slows despite maintaining lifestyle changes

These experiences are entirely normal — but they may also signal it’s time to review your medication with a professional.

What is best for weight loss, Wegovy vs Mounjaro?

Wegovy vs Mounjaro: What’s the Difference?

Both Wegovy and Mounjaro are weekly injectable medications designed for medical weight loss. However, they act on the body in different ways:

Wegovy (Semaglutide):

  • Mimics GLP-1, a hormone that helps reduce appetite, slow stomach emptying, and regulate blood sugar.

  • Used for both weight loss and type 2 diabetes management under different brand names.

Mounjaro (Tirzepatide):

  • Mimics both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide), another hormone involved in appetite and insulin regulation.

  • This dual action may lead to greater weight loss and better metabolic effects in some patients.

Clinical trials suggest that Mounjaro may help some individuals lose more weight, more quickly, compared to semaglutide alone. While individual responses vary, patients switching from Wegovy to Mounjaro often report a renewed boost in results.

Why Consider Switching to Mounjaro?

Here are a few reasons why patients at our clinic have made the switch:

✔ You’ve Plateaued

If your weight loss has stalled for 6+ weeks despite adherence, Mounjaro’s dual-action mechanism may provide an extra push.

✔ You Want Greater Appetite Control

Some patients find that Mounjaro provides stronger hunger suppression — especially in the evening or between meals.

✔ You Struggled with Wegovy’s Side Effects

Although both medications can cause nausea or digestive symptoms, some patients tolerate tirzepatide better. The side effect profile can differ based on your body’s response.

✔ You Have Type 2 Diabetes

Mounjaro is also used to manage blood sugar, so it may be an excellent option if you have coexisting metabolic conditions.

Is It Safe to Switch?

Switching from Wegovy to Mounjaro should always be done under the guidance of a healthcare professional. At Chelsea Green Pharmacy, we offer one-to-one consultations to:

  • Review your current medication and dosing history

  • Assess your progress, side effects, and goals

  • Provide a safe and structured plan for switching to Mounjaro (if appropriate)

  • Monitor your response, dosage adjustments, and well-being over time

You should never stop or change your medication without consulting a pharmacist or prescriber — especially with injectable treatments.

Consult with a health care professional when comparing Wegovy vs Mounjaro.

What to Expect on Mounjaro

Mounjaro is taken once a week by subcutaneous injection, just like Wegovy. It begins at a low dose (usually 2.5mg) and gradually increases over time, based on tolerability and response.

During the first few weeks:

  • You may experience mild nausea or reduced appetite

  • Your hunger cues may change significantly

  • You should follow a balanced, protein-rich diet and stay hydrated

  • Regular check-ins with our pharmacy team are important to assess your progress and comfort

Many patients report feeling “in control” of their eating habits again — often with fewer cravings or emotional triggers.

Ready to Reignite Your Progress? Let’s Talk

If you’ve tried Wegovy and feel your results are slowing, it might be time to consider whether Mounjaro is the next step in your journey. With its dual-action formula, it may help you break through the plateau and reach your goals more comfortably.

At Chelsea Green Pharmacy, we offer confidential, pharmacy-led consultations to assess your suitability and guide you through the Wegovy vs Mounjaro decision with care and expertise.

Book Your Weight Loss Injection Review Today

Take control of your progress with support that’s tailored to you. Whether you’re exploring a switch or starting fresh, we’re here to help you make informed, confident choices.

Contact or visit Chelsea Green Pharmacy today to book your consultation.

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